tag:blogger.com,1999:blog-8859456735165996893.post3037947586631282592..comments2024-03-28T02:36:04.078-07:00Comments on Health Correlator: The 14-percent advantage of eating little and then a lot: Putting it in practiceNed Kockhttp://www.blogger.com/profile/02755560885749335053noreply@blogger.comBlogger13125tag:blogger.com,1999:blog-8859456735165996893.post-23280276054421888902012-09-26T11:29:46.139-07:002012-09-26T11:29:46.139-07:00I do the following:
3 day fast, about 20-22 hour, ...I do the following:<br />3 day fast, about 20-22 hour, and heavy high intensity weight trainig, and eating after it.<br />2 day underfeeding, only prot and fat lunch and full meal dinner. Overeating at weekend.<br />I dont see muscle loss but do you think fasted trainig can cause?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-78354468833591308232012-09-01T10:13:24.200-07:002012-09-01T10:13:24.200-07:00plus, "the closest" is still not "t...plus, "the closest" is still not "the same". This is one reason why so many drugs look so promising in the animal testing phase, but fail when they try them on humans<br /><br />TrinaAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-24604361294338494682012-08-23T09:50:41.521-07:002012-08-23T09:50:41.521-07:00Hi, Razz--
Last time I checked, my BSc, MA, and P...Hi, Razz--<br /><br />Last time I checked, my BSc, MA, and PhD were all still valid. You are welcome to call me, for example, an "idiot." But "uneducated" won't do.<br /><br />I think you are misunderstanding the thrust of the link you cite.<br /><br />Yes, mice as models for diseases in other mammals are extremely valuable. But most researchers acr acutely aware of their limitations as well. Google : mouse models limitations : and you will find a voluminous literature on the topic.<br /><br />I don't know where you get the idea that mice are the most similar animals to humans genetically of all model organisms. (Though I admit that by defining "model organisms" as you like you could probably prove anything.) Mice are more similar to us than fruit flies, certainly, but any primate is more similar to us genetically than any rodent.<br /><br />You might want to take a look at the following paper from the Proceedings of the National Academy of Sciences on the problems with modeling human morbidity with lab rodents.<br /><br />http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852022/?tool=pmcentrez<br /><br />But I suppose the National Academy--like me, apparently--are uneducated.<br /><br />In addition, YOU might want to LIMIT your use of ALL CAPS in your text...it's SCARY.David Isaakhttps://www.blogger.com/profile/04928598446742324391noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-59960492850171996872012-08-11T07:11:45.676-07:002012-08-11T07:11:45.676-07:00Hi Adante. There is no guarantee that it will all ...Hi Adante. There is no guarantee that it will all be body fat, but alternate under/overfeeding tends to push your body in the direction of using stored energy at intervals that do not require muscle breakdown for glucose generation. In that sense, most if not all of the stored energy used, should come from body fat.Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-45193676651590527062012-08-08T13:59:24.271-07:002012-08-08T13:59:24.271-07:00I'm not familiar with the mechanisms here so j...I'm not familiar with the mechanisms here so just wanted to confirm that the 150 calories lost in your example really would be 100% fat? That seems like a very impressive recomp ratio.adantenoreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-2428427075004194072012-08-07T09:40:39.963-07:002012-08-07T09:40:39.963-07:00Extrapolation has to be done very carefully Razz. ...Extrapolation has to be done very carefully Razz. For example, doubling lifespan in mice would be very unlikely to be comparable with doubling lifespan in humans. That’s what David was referring to.<br /><br /> Thanks for commenting.Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-41982169694032055152012-08-06T16:19:27.382-07:002012-08-06T16:19:27.382-07:00Mice are VERY SIMILAR to humans with regard to boi...Mice are VERY SIMILAR to humans with regard to boidy weight regulation. There is a REASON scientists such as Dr. Friedman use them:<br /><br />ONLY Internet FOLKLORE says other otherweise about mice. Mice make AWESOME model organisms. Dr. Fredman specifically CONFIRMED most of his findings in mice WITH HUMANS. <br /><br /><br /> Scientists even refer to them as "furry humans" because they are MOST similar to use GENETICALLY. THEY ARE EXCELLENT.<br /><br />THE CLOSEST TO HUMASN out of ALL model organisms. <br /><br />Reputable site:<br /><br />http://hhmi.org/genesweshare/d130.html<br /><br />The misinformation by uneducated Internet people is SCARY.<br /><br /><br /><br /><br />Great blog, Ned.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-29422287552922121552012-08-06T08:27:19.337-07:002012-08-06T08:27:19.337-07:00Thanks dearieme.Thanks dearieme.Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-20758132661940822692012-08-06T08:26:46.085-07:002012-08-06T08:26:46.085-07:00That is a good point David. There are a number of ...That is a good point David. There are a number of other reasons why research on non-human animals cannot be easily extrapolated to humans. One is the size of our brain and its hunger for glucose; our brain consumes about 5 g/h of glucose, with that number going down and glucose being replaced by ketones as liver glycogen becomes depleted.Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-12867917413836984862012-08-06T03:06:40.846-07:002012-08-06T03:06:40.846-07:00I don't know whether you can get internet acce...I don't know whether you can get internet access to the Beeb, but BBC2 is broadcasting a show this evening (9:00 - 10:00 pm BST) called "Horizon: Eat, Fast, and Live Longer" about 'alternate day fasting'.deariemenoreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-51738883543639316272012-08-05T10:56:28.178-07:002012-08-05T10:56:28.178-07:00Very enjoyable, and I think you are on to somethin...Very enjoyable, and I think you are on to something.<br /><br />Just let me throw in a caveat regarding feeding experiments with mice, though. People are quick to point out that mice aren't humans in terms of nutritional pathways, but they often miss the fact that our lifespans are so different.<br /><br />For example, if a mouse is forced to fast for a day, it is about 0.1%of the typical mouse life span. A comparable fast for a human, if we assume as 70-year lifespan, would be a 35-day fast.<br /><br />It's worse than apples and oranges. A lot of our biochemical reactions run at a similar pace, so there are similarities, but what "a day" means is quite different.<br /><br />So I'm much more taken with your arguments from human overfeeding studies than from mouse lore. (Although it reinforces the argument when they both seem to point in the same direction.)David Isaakhttps://www.blogger.com/profile/04928598446742324391noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-68290759571974959172012-08-05T07:33:58.719-07:002012-08-05T07:33:58.719-07:00Great stuff Ned.Great stuff Ned.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-50274079226371087912012-07-31T08:45:12.771-07:002012-07-31T08:45:12.771-07:00Very Interesting theory , I think I read about it ...Very Interesting theory , I think I read about it some years ago, but I don't remember where.Moira Moralesnoreply@blogger.com