tag:blogger.com,1999:blog-8859456735165996893.post7598756164863434429..comments2024-03-28T02:36:04.078-07:00Comments on Health Correlator: Being glucose intolerant may make you live only to be 96, if you would otherwise live to be 100Ned Kockhttp://www.blogger.com/profile/02755560885749335053noreply@blogger.comBlogger26125tag:blogger.com,1999:blog-8859456735165996893.post-4528170232432328642011-09-26T06:47:24.112-07:002011-09-26T06:47:24.112-07:00Hi David. Another alternative is for the CEO not t...Hi David. Another alternative is for the CEO not to act like an alpha male monkey would, being more of a motivator than a drill sergeant, and reap the benefits in terms of health.<br /><br /> It seems like Alan Mulally generally follows that approach, in an industry where management-employee relations can be quite contentious.Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-51980986070708873122011-09-25T10:32:26.569-07:002011-09-25T10:32:26.569-07:00@Lerner--Some studies show that while the lower-ra...@Lerner--Some studies show that while the lower-ranking elements of the pecking order experience more damaging stress than higher-ranking members, the top dog (or, rather, ape) also experiences a lot of stress.<br /><br />Apparently the best place to be is near the top but not in charge--the Grand Vizier rather than the Caliph. Conultant rather than CEO.David Isaakhttps://www.blogger.com/profile/04928598446742324391noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-41255120704045492742011-09-25T10:28:02.913-07:002011-09-25T10:28:02.913-07:00Apropos of this and your previous post, a recent s...Apropos of this and your previous post, a recent study found that fasting blood glucose is not a predictor of CV problems in T2 diabetics.<br /><br />http://care.diabetesjournals.org/content/34/10/2237<br /><br />High postprandial levels after lunch, however, were predictive. Breakfast wasn't. They do some handwaving to explain that away:<br /><br />http://www.theheart.org/article/1278655.doDavid Isaakhttps://www.blogger.com/profile/04928598446742324391noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-35633819514761533292011-09-24T09:10:09.278-07:002011-09-24T09:10:09.278-07:00Ned:
In answer to your question, pre-Dx, my mothe...Ned:<br /><br />In answer to your question, pre-Dx, my mother ate what was probably a fairly standard American diet, but she had a big garden and ate vegetables from that and shopped at a Coop with organic food.<br /><br />After the Dx (which occurred after a cancer operation), she was put on the high-carb, low-fat ADA diet and lost a lot of weight and her doctor said they wondered if she'd ever had diabetes at all.<br /><br />At that point she reverted to her previous diet and regained all the weight, plus some.<br /><br />At one point, at my suggestion, she tried a LC diet and said she'd never felt so good, but she didn't really understand what carbs are ("But I thought oatmeal and prunes and orange juic were healthy") and abandoned it.<br /><br />In her last years, she was eating what many would consider a healthy diet (lots of vegetables, chicken and fish, and some red meat), but her caregivers believed in low fat, so they'd give her "healthy" organic low-fat brownies and things like that.<br /><br />At that point, I felt that enjoying her food was more important than a low A1c, so I didn't lay down the law. Her doctor and I also agreed that she was taking so much medication for her heart that additional medication for the mild diabetes wasn't a good idea.<br /><br />Lerner: Look into follow-up studies of the infamous Accord study that has doctors telling their diabetic patients to increase their A1cs. It was only the patients who were unable to lower A1c despite masses of drugs who did worse.Gretchenhttps://www.blogger.com/profile/17019921800841883073noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-23398617701521132342011-09-24T08:10:24.098-07:002011-09-24T08:10:24.098-07:00"Cortisol suppresses the immune system. But i..."Cortisol suppresses the immune system. But it also suppresses inflammatory responses. Perhaps these effects occur together for a reason …"<br /><br />I don't believe you can have an inflammatory response which is not mediated by immune cells. Even when twisting your knee, it is the mast cells that excrete the histamine that starts things out. Then you'd eventually end up with macrophages doing the scavenging to clean up.<br /><br />Also, there are studies of monkees/primates whose <b>stress hormone</b> levels are higher as they themselves are lower on the dominance hierarchy. Also there are studies on British civil servants showing the same effect. So I'd guess it was not an idyllic existence for the cavemen either, lolling about stress free :) Most stress might have come from fellow humans rather than predators.<br /><br />And btw, the worst outcome of low cortisol would be an Addisonian Crisis which can = death.Lernerhttps://www.blogger.com/profile/13409056468297249099noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-12163794991817876382011-09-24T08:08:28.805-07:002011-09-24T08:08:28.805-07:00Here is a bit more on IR and Peter’s points, menti...Here is a bit more on IR and Peter’s points, mentioned by gwarm. And, thanks gwarm for raising these issues.<br /><br /> When Peter (Hyperlipid) talks about the benefits of peripheral IR, which is closely related to what he calls physiological IR, he correctly points out that it prevents death, by preventing hypoglycemia.<br /><br /> Looking at glucose levels and how they can vary shows just how this is a very, very good point that should always in the back of anyone’s mind when they think about glucose levels.<br /><br /> In the absence of peripheral IR, how much would it take to lead to severely low blood glucose levels – say, about half of 100 mg/dl?<br /><br /> Well, a person with a blood glucose level of 100 mg/dl will have about 5 g of sugar in the blood:<br /><br /> http://bit.ly/qSLDkd<br /><br /> So it would take the disappearance of 2.5 g of sugar to lead to severely low blood glucose levels. Not life-threatening yet, but low enough to cause some seriously unpleasant symptoms.<br /><br /> How much body movement would consume 2.5 g of sugar, without some form of IR, in this case clearly physiological IR? I am not sure, but I’d say not much. Our brain alone consumes about 5 g of sugar per hour, whether you are sitting quietly or not …Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-81112922660747265682011-09-24T07:53:45.129-07:002011-09-24T07:53:45.129-07:00The thing that I've begun to wonder is this: w...The thing that I've begun to wonder is this: what part of a high serum level of glucose or lipids is the damaging part?<br /><br />IOW, is it peak plasma, is it the total AUC, is it the duration spent over some damaging threshold? <br /><br /><br />Btw, what you say about gradual elevation of glucose reminds me of what is also being talked about again wrt blood pressure and the elderly - specifically cognitive ability and organ perfusion. As you know, once upon a time, 'normal' BP was said to be age + 100, then the goal became to keep it at a low target. But now AFAIK there is a bit of talk again to let it rise.Lernerhttps://www.blogger.com/profile/13409056468297249099noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-85311730880186740332011-09-24T07:40:01.474-07:002011-09-24T07:40:01.474-07:00Here is a bit more on the issue of cortisol levels...Here is a bit more on the issue of cortisol levels raised by gwarm.<br /> <br /> Chronically elevated cortisol, as we see in these traders, is clearly unhealthy:<br /><br /> http://bit.ly/g75Bqg<br /><br /> However, cortisol has a number of body functions, probably some of which we don’t know yet. For example, with very low levels of circulating cortisol, memorization and learning might be impaired:<br /><br /> http://bit.ly/9ZgRtf<br /><br /> An acute increase in cortisol levels, lasting several days, does not seem like such an unnatural thing. Our Paleo ancestors probably faced situations that would lead to such a response, but not in a chronic fashion.<br /><br /> A few sleepless nights don’t sound like such an unnatural thing either. Would all of our Paleo ancestors have 8 h per night of deep, restful sleep, every day? I doubt it. If not, selection pressure would ensue, and cortisol might have been a factor.<br /><br /> Interestingly, an acute increase in cortisol levels, as described above, would have an interesting effect – it would clear acne and temporarily “cure” allergic reactions.<br /><br /> Cortisol suppresses the immune system. But it also suppresses inflammatory responses. Perhaps these effects occur together for a reason …Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-41453461084506615222011-09-24T07:27:55.213-07:002011-09-24T07:27:55.213-07:00Hi Lerner, thanks. The fear-mongering situation th...Hi Lerner, thanks. The fear-mongering situation that has been developing lately regarding blood glucose reminds me a bit of the cholesterol situation – which still persists.<br /><br /> Some may argue that this is all due to measurement. I’d disagree, and argue that among the main problems are bad measurement and bad interpretation of results.<br /><br /> Ignoring measurement is a self-defeating proposition, as someone will surely come up with measurement-based papers and related conclusions in the future. Some of those conclusions will be way off mark, and lead to more fear-mongering.<br /><br /> Long-lived individuals see a gradual increase in average blood glucose levels over time, not a decrease:<br /><br /> http://bit.ly/qdFzabNed Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-34247025169132103232011-09-24T07:18:41.899-07:002011-09-24T07:18:41.899-07:00Hi gwarm. IR is a whole-body measure, but many tis...Hi gwarm. IR is a whole-body measure, but many tissues may present different degrees of IR at different points in time, differentially contributing to the whole-body IR effect.<br /><br /> For example, elevated GH levels tend to lead to whole-body IR in adults, apparently because the liver does not become insulin sensitive at the same speed as muscle tissue becomes IR. The latter is generally a good short-term adaptation – i.e., muscle running more on FFAs and less on glucose is generally a good thing.<br /><br /> Eventually the liver seems to catch up, a long-term compensatory adaptation:<br /><br /> http://bit.ly/jh9wcm<br /><br /> What can lead to elevated GH levels? Glycogen-depleting exercise and intermittent fasting do; they also lead to an increase in cortisol levels.Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-43402191038771228732011-09-23T15:00:13.387-07:002011-09-23T15:00:13.387-07:00yet as things always get complicated, the ACCORD s...yet as things always get complicated, the ACCORD study showed that aggressive lowering of A1c = more death, not less.<br /><br />Also, though I'd always heard that glycation of proteins is irreversible, it turns out that N-acetylcarnosine eyedrops are used in prevention and even reversal of glycation in cataracts:<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/19487926<br /><br />What other areas have treatments to reverse glycation?Lernerhttps://www.blogger.com/profile/13409056468297249099noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-51908663488463378662011-09-23T14:47:50.553-07:002011-09-23T14:47:50.553-07:00@js290: the diagnostic criteria for Type II, from ...@js290: the diagnostic criteria for Type II, from WHO and ADA = fasting blood glucose >126, or OGTT >200 or A1c > 6.5Lernerhttps://www.blogger.com/profile/13409056468297249099noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-46178506974906663902011-09-23T14:44:40.034-07:002011-09-23T14:44:40.034-07:00quoting Gretchen: "It's known that compli...quoting Gretchen: "It's known that complications take about 10 years to show up."<br /><br />This is echoed just now at EASD 2011, re the Hoorn Study:<br /><br />"Glucose disturbances appear years before diabetes diagnosis"<br /><br />http://www.theheart.org/article/1280851.doLernerhttps://www.blogger.com/profile/13409056468297249099noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-4403525112390493462011-09-23T07:33:46.792-07:002011-09-23T07:33:46.792-07:00One thing to consider about low-carb diets is this...One thing to consider about low-carb diets is this 'physiological insulin resistance.' (<a href="http://www.lowcarbconversations.com/344/22-barbara-rose-dean-dwyer-paleo-guy-weston-price-gal-discuss-body-image-more/#comment-306963040" rel="nofollow">linked in that hyperlipid post</a>).<br /><br />And in the comments of hyperlipid: "I've noticed that since I've reduced my carb intake, eating a high-carb meal kicks my butt. I feel like... my blood glucose is through the roof and all my proteins are being glycated!! Seriously, I feel warm all over and tired as if I were having a systemic inflammatory response. Although it may just be my overactive imagination."<br />-<br />What happens when cortisol goes up? example: cortisol goes up from bad sleep (or stressors that cannot be eliminated) leading to->dumping glucose into bloodstream and higher A1C's, AGEs etc (?)gwarmhttps://www.blogger.com/profile/00059000185578090757noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-68427307441424110252011-09-22T18:19:49.680-07:002011-09-22T18:19:49.680-07:00Hi gwarm. Yes, I hear a lot about that carb-loadin...Hi gwarm. Yes, I hear a lot about that carb-loading effect, but haven’t seen a paper discussing it yet.<br /><br /> Keep in mind that the carb-loading may mask reactive hypoglycemia somewhat, making it less accentuated. <br /><br /> And if there is something that is worth catching early is reactive hypoglycemia. The path to hyperglycemia, in the context of T2D, is paved with low blood glucose levels …Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-39340233027534216362011-09-22T18:13:18.865-07:002011-09-22T18:13:18.865-07:00Btw, Helen, thanks for the link. Very interesting....Btw, Helen, thanks for the link. Very interesting.Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-27829441029531527392011-09-22T18:12:47.035-07:002011-09-22T18:12:47.035-07:00Hi Helen. I am becoming increasingly convinced tha...Hi Helen. I am becoming increasingly convinced that diabetes is a compensatory adaptation to protect us from something – the most obvious candidate is hypoglycemia.<br /><br /> That would be an evolved response in polygenic diabetes, suggested by the very high prevalence of this condition in modern populations. Too high for it not to have been evolved. <br /><br /> But I am not sure it would be an evolved response in monogenic diabetes, which is a rare type of diabetes.Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-36150201489638250382011-09-22T18:06:02.855-07:002011-09-22T18:06:02.855-07:00Hi Beth. I think that the 140 rule is a good one. ...Hi Beth. I think that the 140 rule is a good one. I tend to follow it myself.<br /><br /> If you are normoglycemic and older than 40 that will usually mean not eating most industrial carb-rich foods, particularly the ones made from refined wheat.<br /><br /> Postprandial glucose levels in response to the same glucose challenge tend to go up with age in most people, even the very long lived.<br /><br /> Usually eating natural carb-rich foods, such as fruits, as desserts to meals based on protein and/or fat will also lead to lower postprandial blood glucose levels.Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-43071601530122465912011-09-22T17:59:38.491-07:002011-09-22T17:59:38.491-07:00Hi js290. T2D is generally associated with impaire...Hi js290. T2D is generally associated with impaired beta cell function, but still some insulin production.Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-26782134461106709592011-09-22T17:57:46.124-07:002011-09-22T17:57:46.124-07:00Hi Gretchen, thanks for sharing and good points. A...Hi Gretchen, thanks for sharing and good points. Anecdotal, but powerful! What has your mother eaten before and after the diagnosis?Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-82634345996663544342011-09-22T06:43:22.889-07:002011-09-22T06:43:22.889-07:00One thing about the glucose tolerance test is the ...One thing about the glucose tolerance test is the 'physiological insulin resistance' of those who eat low-carb to consider. Links to a post on hyper-lipid:<br /><br /><a href="http://www.lowcarbconversations.com/344/22-barbara-rose-dean-dwyer-paleo-guy-weston-price-gal-discuss-body-image-more/#comment-306963040" rel="nofollow">http://www.lowcarbconversations.com/344/22-barbara-rose-dean-dwyer-paleo-guy-weston-price-gal-discuss-body-image-more/#comment-306963040</a><br /><br />Hyperlipid: "However, while muscles are in "refusal mode" for glucose the least input, from food or gluconeogenesis, will rapidly spike blood glucose out of all proportion. This is fine if you stick to LC in your eating. It also means that if you take an oral glucose tolerance test you will fail and be labelled diabetic. In fact, even a single high fat meal can do this, extending insulin resistance in to the next day. Here's a reference for this.<br /><br />The general opinion in LC circles is that you need 150g of carbohydrate per day for three days before an oral glucose tolerance test [link].<br /><br />I did this carb loading thing, then performed my own OGTT. It came out very normal except for mild reactive hypoglycaemia. "<br />--<br />Now that I eat higher carb (try 150g/day for 3 days first) I have noticed sweet potatoes (cooked sweet potato w/o skin... and you can eat w/ tsp of cinnamon and the fructose in the potato will lower the glycemic impact too) don't make me hypoglycemic anymore and now I eat 2-3 potatoes a day but I will have to try it with white rice (which has no natural nutrients, fiber/prebiotic and is higher glycemic) to see if I'm good with that "safe starch" (but white rice is full of undesirable fortified b vitamins/folic-acid).gwarmhttps://www.blogger.com/profile/00059000185578090757noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-10825999913156959162011-09-21T18:07:07.985-07:002011-09-21T18:07:07.985-07:00I do wonder if the stress I've had about my hi...I do wonder if the stress I've had about my highish glucose levels are more damaging than the highish glucose levels themselves. Especially since it was doubtful that I was on a "damaging diet" to begin with, and low-carb and low-fat diets and a 30 lb weight loss (from 155 to 125) brought the same 0.4 reduction in my A1c (6.4 to 6.0) and no more, and I was an A student in following that low-carb diet. <br /><br />I'm sure this is vastly different from many other people's experiences - for instance, my father-in-law went from an A1c of 12 to one of 5.7 mainly by taking Metformin (which did nothing for me). <br /><br />He falls into a "classic Type II diabetes" profile, while I don't.<br /><br />In any case, your post makes a good points - and helps me put my stress about my BG in perspective. <br /><br />And, like you say, compromised glucose control does not always represent the same systemic stuff going on - different causes come with different effects - poor outcomes related to high blood sugars surely have a good deal with the sugars themselves, but also have to do with the things that typically cause them and go along with them - like hypertension and high triglycerides. <br /><br />For instance, I think I may have a monogenic form of diabetes. (Of interest: "Clues to finding further causes for monogenic diabetes" http://www.sciencedaily.com/releases/2011/09/110921074734.htm)<br /><br />In one form (MODY 2), despite having A1c's between 6.0 and 7.0, patients don't apparently have increased cardiovascular or microvascular risks. Triglycerides tend to be low, and obesity is not common. (Thought this might be me, as I fit the profile, but genes say no.)Mavishttps://www.blogger.com/profile/06994797939492751433noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-65179647098691002772011-09-21T08:15:15.145-07:002011-09-21T08:15:15.145-07:00translate polisch-english
http://tinyurl.com/3p4p...translate polisch-english <br />http://tinyurl.com/3p4p77k<br /><br />Ladies and Gentlemen,<br />I wanted to give you information on the role of glucose in people taking Nutrition<br />Optimal (®), because there are different views here, which have nothing in common with reality.<br /><br />Well, at the optimal normal blood glucose level is higher than in other people using other models of nutrition and averages 110-140 mg%. And this value is correct sugar levels. Administration of glucose, for example, the performance of the so-called. attempts to sugar curve, increases in glucose levels, which slowly decreases the level of what doctors interpret as pathological curve of corn and try to convince the test that their sugar curve indicates the presence of type II diabetes.<br /><br />For each person applying Optimum Nutrition (®) called. Sugar is an attempt to "pathological" because the body is not adapted to the rapid combustion or processing large amounts of glucose,<br />especially given rapidly. Since the optimal carbohydrate eating enough, their bodies are adapted to supply a small amount of carbohydrates.<br /><br />Of the three gram molecule arises a glucose fatty acid gram molecule<br />in the chain, for example, a complex of eighteen carbons and eight gram molecule oxygen. This oxygen is used for internal respiration. Formula reaction:<br /><br />3C6H12O6 --> C18H36O2 + 8O2<br /><br />3 mole weighs 540 g of glucose, which is formed from 284 g of fatty acid stearic<br />and 256 g of oxygen, that is -<br /><br />with 100 g of glucose on 53g of processed fatty acid, stearic<br />formed 47, 4g of oxygen, or about 33 liters of oxygen (O2).M & Mhttps://www.blogger.com/profile/14295468760852417023noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-76279152390775549422011-09-19T12:30:26.018-07:002011-09-19T12:30:26.018-07:00Hmmm. Sure makes me wonder how "Wheat Belly&q...Hmmm. Sure makes me wonder how "Wheat Belly" Davis' prescription to keep postprandrial BG under 140 fits in. He's essentially saying everyone needs to be on a nearly ketogenic diet. I'm not ready to go there just yet!Beth@WeightMavenhttps://www.blogger.com/profile/17725838221780385439noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-5061555658808112682011-09-19T07:59:48.592-07:002011-09-19T07:59:48.592-07:00What does "Type 2 diabetic" mean exactly...What does "Type 2 diabetic" mean exactly? Beta cell damage and no longer capable of producing insulin?js290noreply@blogger.com