tag:blogger.com,1999:blog-8859456735165996893.post4125734191727948674..comments2024-03-28T02:36:04.078-07:00Comments on Health Correlator: Vitamin D deficiency, seasonal depression, and diseases of civilizationNed Kockhttp://www.blogger.com/profile/02755560885749335053noreply@blogger.comBlogger19125tag:blogger.com,1999:blog-8859456735165996893.post-82584878925827862522015-07-17T23:51:50.283-07:002015-07-17T23:51:50.283-07:00You should never ignore the deep relationship betw...You should never ignore the deep relationship between Vitamin D and depression. This vitamin could actually save you from the distress, sadness, pessimism, misery and sorrow.<br />niacin depressionhttp://www.amidepressedtest.comnoreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-51734153670579002722012-05-21T17:39:58.320-07:002012-05-21T17:39:58.320-07:00A comment on tanning booths, related to the discus...A comment on tanning booths, related to the discussion above: There is strong evidence that they are NOT safe, at least with the current technology used.Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-59578281198424415872011-09-14T23:31:10.386-07:002011-09-14T23:31:10.386-07:00Mark Sisson had a post on foods to eat to protect ...Mark Sisson had a post on foods to eat to protect against the sun damage <a href="http://www.marksdailyapple.com/8-natural-ways-to-prevent-a-sunburn-and-sunscreens-not-one-of-them/" rel="nofollow">http://www.marksdailyapple.com/8-natural-ways-to-prevent-a-sunburn-and-sunscreens-not-one-of-them/</a> He kind of looks sun damaged himself (some say: <a href="http://www.longecity.org/forum/topic/25988-i-have-yet-to-see-somebody-who-looks-as-young-as-they-claim/page__st__540__p__366036#entry366036" rel="nofollow">http://www.longecity.org/forum/topic/25988-i-have-yet-to-see-somebody-who-looks-as-young-as-they-claim/page__st__540__p__366036#entry366036</a> <a href="http://i247.photobucket.com/albums/gg158/MDA2008/MDA2009/BodyFat.jpg" rel="nofollow">http://i247.photobucket.com/albums/gg158/MDA2008/MDA2009/BodyFat.jpg</a>)gwarmhttps://www.blogger.com/profile/00059000185578090757noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-69833708748560433502011-09-14T23:23:33.858-07:002011-09-14T23:23:33.858-07:00DrGreger had this to say about tanning beds:
http:...DrGreger had this to say about tanning beds:<br /><a href="http://www.youtube.com/watch?v=jPjd_W5EfGU&feature=BFa&list=PL53AA35449C7DD652&lf=PlayList#t=29m30s" rel="nofollow">http://www.youtube.com/watch?v=jPjd_W5EfGU&feature=BFa&list=PL53AA35449C7DD652&lf=PlayList#t=29m30s</a><br /><br />From his 'tanning beds.pdf'<br /><a href="http://is.gd/vT4Ogh" rel="nofollow">http://is.gd/vT4Ogh</a> "<br />Multiple studies have shown concerning evidence that tanning bed patrons are receiving<br />much higher doses of UV radiation than they<br />would from summer sun exposure. Summer solar<br />noon output in Washington, DC, is estimated to<br />be 48 W/m2<br />UVA and 0.18 W/m2<br />erythemally<br />weighted UVB (20). In contrast, in a study in<br />North Carolina, UV output in standard tanning<br />facility beds was found to be much higher, with a<br />mean of 192.1 W/m2<br />UVA and 0.35 W/m2<br />erythemally weighted UVB (23). In a study by the FDA,<br />for a typical tanner (20 sessions at two minimal<br />erythema dose (MED)/session), the annual UVA<br />doses from commonly used fluorescent sunlamps<br />were 0.3–1.2 times that received from the sun. For<br />a frequent tanner (100 sessions at four MED/<br />session), the annual UVA doses from fluorescent<br />sunlamps were 1.2–4.7 times that received from<br />the sun and 12 times for recently available, highpressure sunlamps (20).<br />Another study in Switzerland found that sunbed<br />emission spectra are similar to the sun spectrum in<br />the UVB range, but reach values 10–15 times higher<br />in the UVA range (24) An average erythemaeffective irradiance of 0.33 W/m2<br />was determined<br />for sunbeds. This corresponds to a UV index of 13,<br />which is significantly higher than the UV index of<br />8.5 of the high summer sun at noon at intermediate<br />latitudes. In such a sunbed, the MED threshold of<br />a person with skin type II is reached after 12.6<br />minutes (250 J/m2<br />), and that of a person with skin<br />type III after 17.7 minutes (350 J/m2<br />). As visitors of<br />tanning salons with skin types II and III spend, on<br />average, 20 minutes in sunbeds, overexposure to<br />UV radiation is very likely (25).<br />...<br />y<br />UV carcinogenesis pathway<br />UV irradiation causes DNA damage that can lead to<br />carcinogenesis. Sunburn is primarily caused by<br />UVB (31). UVB is also far more effective at inducing<br />inflammation than UVA, and in murine studies, it<br />has been estimated to be 1000–10,000 times more<br />effective for inducing skin cancer (32,33). In the<br />past, UVB was considered the only carcinogenic<br />part of the solar spectrum, through the generation<br />of cyclobutane pyrimidine dimers (CPDs) that<br />cause C →T and CC →TT mutations, also known as<br />UVB fingerprint mutations (34). Recent evidence<br />suggests that radiation in the UVA range can also<br />trigger DNA damage via cyclobutane pyrimidine<br />dimer formation and C →T mutations (35,36). Normally, p53, a tumor-suppressor gene, is upregulated<br />by sunlight exposure, leading to increased DNA<br />repair, cell cycle arrest, and apoptosis of damaged<br />keratinocytes. However, p53 itself is also susceptible<br />to mutagenesis, and sunlight-induced p53 mutations have been found in skin precancers and even<br />in sun-exposed skin, rendering these cells apoptosis resistant (37). In vitro studies have confirmed<br />that chronic UVA exposures at environmentally relevant doses can induce malignant transformation<br />of human keratinocytes associated with acquired<br />apoptotic resistance. Malignant transformation<br />was established by the production of aggressive<br />squamous cell carcinomas (SCCs) after inoculation<br />of cells into nude mice (38)."<br /><br />--<br />And I believe he lowered his VitD supplement recommendations<br /><br /><a href="http://www.longecity.org/forum/topic/51291-vitamin-d-20n-30ngml-recommended-over-50-60ngml/" rel="nofollow">http://www.longecity.org/forum/topic/51291-vitamin-d-20n-30ngml-recommended-over-50-60ngml/</a>gwarmhttps://www.blogger.com/profile/00059000185578090757noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-728619140492814442011-07-01T11:30:22.293-07:002011-07-01T11:30:22.293-07:00hello, i think that this post is the best that i h...hello, i think that this post is the best that i have read because has useful information.Invertir en orohttp://www.ibericaconsultores.com/inversion-en-oro/noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-14601472794034794352011-04-05T08:46:49.667-07:002011-04-05T08:46:49.667-07:00I've been reading a lot about vitamins and I t...I've been reading a lot about vitamins and I think we can't ignore this useful information, I think you're doing an interesting post, specially with this sources and it'd be nice if you can add more information about the calcipherol. 2j3jcheap viagrahttp://www.xlpharmacy.comnoreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-73942272532276571932010-02-03T01:51:25.519-08:002010-02-03T01:51:25.519-08:00I know when I was using them for 10 mins a week, I...I know when I was using them for 10 mins a week, I felt a definite improvement in mood. Thanks for the feedback.Ellenhttps://www.blogger.com/profile/14287083009456218214noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-37751508979671048742010-02-02T17:58:06.700-08:002010-02-02T17:58:06.700-08:00This comment has been removed by the author.Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-91351297742808685282010-02-02T17:56:33.243-08:002010-02-02T17:56:33.243-08:00This comment has been removed by the author.Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-73597385497635942192010-02-02T14:27:42.150-08:002010-02-02T14:27:42.150-08:00Ned, what's your opinion of tanning beds?Ned, what's your opinion of tanning beds?Ellenhttps://www.blogger.com/profile/14287083009456218214noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-50866606170509698112010-02-02T13:26:14.204-08:002010-02-02T13:26:14.204-08:00The Vitamin D Council, Dr. Cannell points out
in r...The Vitamin D Council, Dr. Cannell points out<br />in response to letters into him that Vitamin A<br />blocks the benefits of Vit D3 supplementation.<br /><br />This link to letters regarding autism. As Dr. Cannell points out, probably not all autistic<br />persons will benefit from Vit D supplementation...but it sure seems to raise the spirits of many who do supplement Vit D3 up to 60-80ng/ml serum.<br /><br />http://www.vitamindcouncil.org/newsletter/2008-june.shtmldexteryhttps://www.blogger.com/profile/17512541128451523564noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-2547884084690898312010-02-02T06:44:18.700-08:002010-02-02T06:44:18.700-08:00Hi Jack.
The 50,000 IU per week is still below th...Hi Jack.<br /><br />The 50,000 IU per week is still below the maximum recommended 10,000 IU per day (or 70,000 IU per week). <br /><br />Also, the doctor seems to think that low vit. D problems may be resolved with added vit. D, without the need for added vit. A, calcium or magnesium. This seems reasonable to me.<br /><br />What I would do if I were you is to ask the doctor about the article by Tuohimaa and colleagues (full ref. at the end of the post), which is recent (2009), and its implications vis-a-vis your wife's case.Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-43881408377976105072010-02-01T18:28:10.860-08:002010-02-01T18:28:10.860-08:00My wife has very low vitamin D of 15ng/ml in spite...My wife has very low vitamin D of 15ng/ml in spite of taking 1000 IU/day in gelcap. She can not tolerate cod liver oil. Her doctor prescribed 50,000 IU vitamin D3 per week in a single pill, and made no mention of need for added vitamin A, calcium and magnesium. What is your opinion about taking vitamin D in this manner?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-25766225896638625002010-02-01T18:18:55.046-08:002010-02-01T18:18:55.046-08:00Scott:
I would not be surprised, but I don't ...Scott:<br /><br />I would not be surprised, but I don't think the effect of age is dramatic. Sunlight exposure leads to significant vit. D production even in the elderly.<br /><br />Ross:<br /><br />You may be right. The article emphasizes chronic hyperv. D effects. In fact, it shows a photo of the same mice at 4 months of age, and they look the same. By the way, I don't think blood tests are very effective at measuring vit. D, because vit. D is stored in fat tissue and has a long half-life. That is, blood tests likely underestimate vit. D accumulated in the body. Better measure the hormones - calcidiol and calcitriols.<br /><br />dr moron:<br /><br />Mr. Obama needs to hear from you!Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-21866189424362163742010-02-01T17:29:32.723-08:002010-02-01T17:29:32.723-08:00thanks ned.
"Sunlight exposure would probabl...thanks ned.<br /><br />"Sunlight exposure would probably give you more vitamin D, and in a safer way, than supplementation."<br /><br />ain't no sunshine (as bill withers might sing) in the uk this time of year<br /><br />"If I were you, I would check with a doctor to see if everything is okay."<br /><br />ha in this country? doctor would laugh in your face then tell u to stop wasting his time with such trivial nonsense. even getting tested for a semi-serious condition like celiac disease takes over 6 months (no exaggeration - i asked for a test in september, the biopsy is scheduled for march). unless u have cancer they dont want to know! <br /><br />not so bad really, in my expereince most doctors are idiots who dont know what they are talking about so i wouldnt trust one as far as i could throw his fat paycheck. when u consider that 14% of UK doctors dont know their arse from their elbow it really does make u wanna live healthy so u never have to see one!dr moronhttp://www.drmoron.comnoreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-28240591474204620132010-02-01T14:57:53.987-08:002010-02-01T14:57:53.987-08:00I think this article exaggerates the risk of hyper...I think this article exaggerates the risk of hypervitaminosis D. While there have been cases of people obtaining too much Vitamin D from supplements without any sensitizing condition (like sarcoidosis), they are so extraordinarily rare that you can count them on two hands. Further, in all cases, it required months of excessive doses before serious health consequences appeared. For 99+% of people, 4000-10,000IU/day of Vitamin D3 will be well tolerated.<br /><br />I do agree that people taking significant daily doses of D3 would be smart to get their levels checked every six months or so (with a goal of 50-70ng/ml 25(OH)D3) until they know their body's needs. For my wife, 4000IU/day yielded ~50ng/ml and 6000IU/day yielded 60ng/ml, so she's sticking with 6000IU/day and annual tests from now on. It takes me 10,000IU/day to have the same levels.Unknownhttps://www.blogger.com/profile/15898029498707012275noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-49636525415593447352010-02-01T09:29:12.472-08:002010-02-01T09:29:12.472-08:00I thought that I had heard somewhere that the abil...I thought that I had heard somewhere that the ability of our skin to synthesize vitamin D diminishes as we hit middle age due to progressive thinning of the skin and that therefore supplementation remains important, even if you still get a tan when older. Thoughts?<br /><br />Scott WScott Whttps://www.blogger.com/profile/10687098328064801055noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-75909259110315757682010-02-01T05:44:57.838-08:002010-02-01T05:44:57.838-08:00From my reading of the article, my guess is that t...From my reading of the article, my guess is that the hair loss and wrinkles are due to accelerated aging because of hypervitaminosis D.<br /><br />Humans and mice have different physiologies, and you seem to be still below the 10,000 IU upper limit, even with the supplementation.<br /><br />If I were you, I would check with a doctor to see if everything is okay.<br /><br />Sunlight exposure would probably give you more vitamin D, and in a safer way, than supplementation.<br /><br />Cod liver oil also can lead to hypervitaminosis A.Ned Kockhttps://www.blogger.com/profile/02755560885749335053noreply@blogger.comtag:blogger.com,1999:blog-8859456735165996893.post-23075706109734709682010-01-31T15:52:18.939-08:002010-01-31T15:52:18.939-08:00why does the vitamin D mouse have no hair? did it ...why does the vitamin D mouse have no hair? did it fall out because of too much D (the accelerated aging u mentioned), was it born like this as a result of the vitamin D mutation, or did the scientists deliberately use a hairless strain to more clearly show the wrinkles caused by vitamin D? if its because the hair fell out because of D then that is worrying as i've been supplementing with high strength (5000 IU/day) vit D capsules for a while (since i found out i had abnormally low blood calcium levels despite eating lots of calcium-rich food). i also take cod liver oil supplements which have vitamin D...<br /><br />great blog by the way. im impressed u manage to bash out a post of such high qualidad every day. keep up the good work!winnie mandelahttp://www.sexgrease.comnoreply@blogger.com